The cradle of the Santhal Missions for the Salesians however turned out to be Azimganj. In 1957 Fr. John Topno, while staying at Berhampore, launched out into the interior villages of the district contacted many of the Santhal Catholics who had migrated from East Pakistan. Soon many more accepted the Christian faith and thus several Christian communities were established. In December 1964 Fr. Sergi was sent to Azimgnaj to build the centre there. With these background pioneering efforts, Don Bosco Welfare Centre, Azimganj was founded on 18^th July 1966 with the opening of the boarding school with 26 Santal boys. A school of some sorts was already begun in the month of March, mainly for the Santhali children. The Sisters of Charity arrived in 1972 and were great collaborators of the Salesians in the Santhal Mission, particularly taking care of the Santhal girls. The construction of the new school building was begun in 1976 by Fr. G. Alakulam. Fr. Sebastian Alencherril started Non-formal Training sections in carpentry and tailoring, but the experiment did not last very long. Fr. Joseph Cherian procured land at the neighbouring Chandabag to make the centre self-sufficient and to impart agricultural training to the boys. The Bengali medium Co-educational High School received the Governmental recognition on 6 May 1983.

While there was a concerted effort at missionary work ad gentes, the progress of the mission was very much facilitated by the School and the boarding which helped to bring the Salesians into contact with the numerous Santhals of the villages around. There exists today a Boarding for over 200 Santhal tribal boys from classes 5 to 10, and a flourishing co-ed day school for 1200 students (Primary and Secondary).